Rufinamide in patients with Lennox-Gastaut syndrome
نویسندگان
چکیده
منابع مشابه
Treating Lennox–Gastaut syndrome in epileptic pediatric patients with third-generation rufinamide
Lennox-Gastaut syndrome (LGS) is a rare but debilitating pediatric epileptic encephalopathy characterized by multiple intractable seizure types. Treatment of LGS is challenging because of the small number of antiepileptic drugs (AEDs) which are effective for this syndrome, as well as the need for polytherapy in the majority of patients. This review focuses on the treatment of LGS with rufinamid...
متن کاملRufinamide in children and adults with Lennox–Gastaut syndrome: First Italian multicenter experience
This is the first multicenter Italian experience with rufinamide as an adjunctive drug in children, adolescents and adults with Lennox-Gastaut syndrome. The patients were enrolled in a prospective, add-on, open-label treatment study from 11 Italian centers for children and adolescent epilepsy care. Forty-three patients (26 males, 17 females), aged between 4 and 34 years (mean 15.9 ± 7.3, median...
متن کاملRufinamide as an adjuvant treatment in children with Lennox-Gastaut syndrome
PURPOSE To evaluate the efficacy of rufinamide as an add-on treatment in children and adolescents with Lennox-Gastaut syndrome (LGS). METHODS The study was an open-label, observational clinical trial of rufinamide as an add-on treatment in intractable LGS patients. This intent-to-treat trial included 4 weeks of scheduled titrated doses and a 12-week maintenance phase with a target dose of 20-...
متن کاملLennox-Gastaut syndrome
بيصت ةديدش ةيعرص ةمزلاتم يه وتساج سكونيل ةمزلاتم ةرركتمو ةعونتم ةيبصع تاجنشت ةباصإب زيمتتو لافطلأا ةئيطب ةيئابرهك تانحشو روهدتم ينهذ رخأتب ةبوحصم نادقفب ةبوحصلما ةيبصعلا تاجنشتلا لثتمو .غامدلا طيطختب ةيعون روهدتو ةيدسلجا تاباصلإاب ةروطخ طوقسلاو ةكرلحا ةلوهسب بيجتست لا تاجنشتلا هذه نأ ملعلا عم .ةيمويلا ةايلحا .ضرغلا اذهل ديامانيفورلا راقع ريوطت تم اًيلاحو يئاودلا جلاعلل ضعب مادختسا نكميف يئاودلا ...
متن کاملUpdate on the management of Lennox-Gastaut syndrome with a focus on rufinamide
OBJECTIVE This review summarizes the treatment of Lennox-Gastaut syndrome, an intractable epileptic encephalopathy of early childhood. In particular, the review focuses on rufinamide, a recently released anticonvulsant medication with reported effectiveness in this epilepsy syndrome. METHODS A systematic literature search (PubMed) was performed to review the existing literature pertaining to ...
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ژورنال
عنوان ژورنال: Nursing: Research and Reviews
سال: 2016
ISSN: 2230-522X
DOI: 10.2147/nrr.s116114